HMM Summary Page: TIGR02412

Functionaminopeptidase N
Gene SymbolpepN
Trusted Cutoff591.20
Domain Trusted Cutoff591.20
Noise Cutoff412.75
Domain Noise Cutoff412.75
Isology Typeequivalog
EC Number3.4.11.2
HMM Length832
AuthorHaft DH
Entry DateDec 22 2004 4:28PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis family is a subset of the members of the zinc metallopeptidase family M1 (PF01433), with a single member characterized in Streptomyces lividans 66 and designated aminopeptidase N. The spectrum of activity may differ somewhat from the aminopeptidase N clade of E. coli and most other Proteobacteria, well separated phylogenetically within the M1 family. The M1 family also includes leukotriene A-4 hydrolase/aminopeptidase (with a bifunctional active site).
ReferencesRM 7909302 RT The aminopeptidase N-encoding pepN gene of Streptomyces lividans 66. RA Butler MJ, Aphale JS, Binnie C, DiZonno MA, Krygsman P, Soltes GA, Walczyk E, Malek LT. RL Gene. 1994 Apr 8;141(1):115-9.