HMM Summary Page: TIGR02411

Functionleukotriene A-4 hydrolase/aminopeptidase
Trusted Cutoff761.70
Domain Trusted Cutoff761.70
Noise Cutoff526.00
Domain Noise Cutoff526.00
Isology Typeequivalog
EC Number3.3.2.6 3.4.11.-
HMM Length600
AuthorHaft DH
Entry DateDec 22 2004 2:35PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family represent a distinctive subset within the zinc metallopeptidase family M1 (PF01433). The majority of the members of PF01433 are aminopeptidases, but the sequences in this family for which the function is known are leukotriene A-4 hydrolase. A dual epoxide hydrolase and aminopeptidase activity at the same active site is indicated. The physiological substrate for aminopeptidase activity is not known.
ReferencesDR PFAM; PF01433; Peptidase family M1 RN [1] RM 15339917 RT Leukotriene A4 hydrolase/aminopeptidase, the gatekeeper of chemotactic leukotriene B4 biosynthesis. RA Haeggstrom JZ. RL J Biol Chem. 2004 Dec 3;279(49):50639-42. RN [2] RM 11601994 RT Saccharomyces cerevisiae leukotriene A4 hydrolase: formation of leukotriene B4 and identification of catalytic residues. RA Kull F, Ohlson E, Lind B, Haeggstrom JZ. RL Biochemistry. 2001 Oct 23;40(42):12695-703.