| Accession | TIGR02397 |
| Name | dnaX_nterm |
| Function | DNA polymerase III, subunit gamma and tau |
| Gene Symbol | dnaX |
| Trusted Cutoff | 250.00 |
| Domain Trusted Cutoff | 200.00 |
| Noise Cutoff | 149.80 |
| Domain Noise Cutoff | 149.80 |
| Isology Type | equivalog |
| EC Number | 2.7.7.7 |
| HMM Length | 355 |
| Mainrole Category | DNA metabolism |
| Subrole Category | DNA replication, recombination, and repair |
| Gene Ontology Term | GO:0003887: DNA-directed DNA polymerase activity molecular_function |
| | GO:0006260: DNA replication biological_process |
| | GO:0009360: DNA polymerase III complex cellular_component |
| Author | Haft DH |
| Entry Date | Dec 10 2004 9:30AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This model represents the well-conserved first ~ 365 amino acids of the translation of the dnaX gene. The full-length product of the dnaX gene in the model bacterium E. coli is the DNA polymerase III tau subunit. A translational frameshift leads to early termination and a truncated protein subunit gamma, about 1/3 shorter than tau and present in roughly equal amounts. This frameshift mechanism is not necessarily universal for species with DNA polymerase III but appears conserved in the exterme thermophile Thermus thermophilis. |
| References | RN [1]
RM 9209069
RT Conservation of the Escherichia coli dnaX programmed ribosomal frameshift signal in Salmonella typhimurium.
RA Blinkova A, Burkart MF, Owens TD, Walker JR.
RL J Bacteriol. 1997 Jul;179(13):4438-42.
RN [2]
RM 9341154
RT Thermus thermophilis dnaX homolog encoding gamma- and tau-like proteins of the chromosomal replicase.
RA Yurieva O, Skangalis M, Kuriyan J, O'Donnell M.
RL J Biol Chem. 1997 Oct 24;272(43):27131-9. |
| Genome Property | GenProp0263: DNA polymerase III, bacterial (HMM) |
| | GenProp0799: bacterial core gene set, exactly 1 per genome (HMM) |
