HMM Summary Page: TIGR02397

FunctionDNA polymerase III, subunit gamma and tau
Gene SymboldnaX
Trusted Cutoff250.00
Domain Trusted Cutoff200.00
Noise Cutoff149.80
Domain Noise Cutoff149.80
Isology Typeequivalog
EC Number2.7.7.7
HMM Length355
Mainrole CategoryDNA metabolism
Subrole CategoryDNA replication, recombination, and repair
Gene Ontology TermGO:0003887: DNA-directed DNA polymerase activity molecular_function
GO:0006260: DNA replication biological_process
GO:0009360: DNA polymerase III complex cellular_component
AuthorHaft DH
Entry DateDec 10 2004 9:30AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model represents the well-conserved first ~ 365 amino acids of the translation of the dnaX gene. The full-length product of the dnaX gene in the model bacterium E. coli is the DNA polymerase III tau subunit. A translational frameshift leads to early termination and a truncated protein subunit gamma, about 1/3 shorter than tau and present in roughly equal amounts. This frameshift mechanism is not necessarily universal for species with DNA polymerase III but appears conserved in the exterme thermophile Thermus thermophilis.
ReferencesRN [1] RM 9209069 RT Conservation of the Escherichia coli dnaX programmed ribosomal frameshift signal in Salmonella typhimurium. RA Blinkova A, Burkart MF, Owens TD, Walker JR. RL J Bacteriol. 1997 Jul;179(13):4438-42. RN [2] RM 9341154 RT Thermus thermophilis dnaX homolog encoding gamma- and tau-like proteins of the chromosomal replicase. RA Yurieva O, Skangalis M, Kuriyan J, O'Donnell M. RL J Biol Chem. 1997 Oct 24;272(43):27131-9.
Genome PropertyGenProp0263: DNA polymerase III, bacterial (HMM)
GenProp0799: bacterial core gene set, exactly 1 per genome (HMM)