HMM Summary Page: TIGR02385

Functionaddiction module toxin, RelE/StbE family
Trusted Cutoff27.90
Domain Trusted Cutoff27.90
Noise Cutoff27.00
Domain Noise Cutoff27.00
Isology Typesubfamily
HMM Length88
Mainrole CategoryCellular processes
Subrole CategoryToxin production and resistance
AuthorHaft DH
Entry DateNov 30 2004 4:48PM
Last ModifiedFeb 14 2011 3:27PM
CommentPlasmids may be maintained stably in bacterial populations through the action of addiction modules, in which a toxin and antidote are encoded in a cassette on the plasmid. In any daughter cell that lacks the plasmid, the toxin persists and is lethal after the antidote protein is depleted. Toxin/antitoxin pairs are also found on main chromosomes, and likely represent selfish DNA. Sequences in the seed for this alignment all are found adjacent to RelB/DinJ family antitoxin genes (TIGR02384), as are most genes found by the resulting model. StbE from Morganella morganii plasmid R485 shows typical behaviour for an addiction module toxin. It cannot be cloned without its partner (the antitoxin), whereas its partner cannot confer plasmid stability without StbE.
ReferencesDR PFAM; PF05016; Plasmid stabilization system protein RN [1] RM 9829958 RT A family of stability determinants in pathogenic bacteria. RA Hayes F. RL J Bacteriol. 1998 Dec;180(23):6415-8.
Genome PropertyGenProp0321: toxin-antitoxin system, type II (HMM)
GenProp0324: addiction module, RelE-RelB class (HMM)