HMM Summary Page: TIGR02384

Functionaddiction module antitoxin, RelB/DinJ family
Trusted Cutoff45.65
Domain Trusted Cutoff45.65
Noise Cutoff33.45
Domain Noise Cutoff33.45
Isology Typesubfamily
HMM Length85
Mainrole CategoryCellular processes
Subrole CategoryToxin production and resistance
AuthorHaft DH
Entry DateNov 30 2004 4:35PM
Last ModifiedFeb 14 2011 3:27PM
CommentPlasmids may be maintained stably in bacterial populations through the action of addiction modules, in which a toxin and antidote are encoded in a cassette on the plasmid. In any daughter cell that lacks the plasmid, the toxin persists and is lethal after the antidote protein is depleted. Toxin/antitoxin pairs are also found on main chromosomes, and likely represent selfish DNA. Sequences in the seed for this alignment all were found adjacent to toxin genes. The resulting model appears to describe a narrower set of proteins than Pfam model PF04221, although many in the scope of this model are not obviously paired with toxin proteins. Several toxin/antitoxin pairs may occur in a single species.
Genome PropertyGenProp0321: toxin-antitoxin system, type II (HMM)