HMM Summary Page: TIGR02381

Functioncold shock domain protein CspD
Gene SymbolcspD
Trusted Cutoff115.40
Domain Trusted Cutoff115.40
Noise Cutoff113.00
Domain Noise Cutoff113.00
Isology Typeequivalog
HMM Length68
Mainrole CategoryDNA metabolism
Subrole CategoryDNA replication, recombination, and repair
Gene Ontology TermGO:0008156: negative regulation of DNA replication biological_process
GO:0009409: response to cold biological_process
AuthorHaft DH
Entry DateNov 24 2004 2:23PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM represents what appears to be a phylogenetically distinct clade, containing E. coli CspD (SP|P24245) and related proteobacterial proteins within the larger family of cold shock domain proteins described by Pfam HMM PF00313. The gene symbol cspD may have been used idependently for other subfamilies of cold shock domain proteins, such as for B. subtilis CspD. These proteins typically are shorter than 70 amino acids. In E. coli, CspD is a stress response protein induced in stationary phase. This homodimer binds single-stranded DNA and appears to inhibit DNA replication [1].
ReferencesDR PFAM; PF00313; CSD RN [1] RM 11260474 RT CspD, a novel DNA replication inhibitor induced during the stationary phase in Escherichia coli. RA Yamanaka K, Zheng W, Crooke E, Wang YH, Inouye M. RL Mol Microbiol. 2001 Mar;39(6):1572-84.