HMM Summary Page: TIGR02370

Functionmethyltransferase cognate corrinoid proteins, Methanosarcina family
Trusted Cutoff215.30
Domain Trusted Cutoff215.30
Noise Cutoff184.95
Domain Noise Cutoff184.95
Isology Typesubfamily_domain
HMM Length197
AuthorHaft DH
Entry DateNov 5 2004 2:41PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model describes a subfamily of the B12 binding domain (PF02607, PF02310) proteins. Members of the seed alignment include corrinoid proteins specific to four different, mutally non-homologous enzymes of the genus Methanosarcina. Three of the four cognate enzymes (trimethylamine, dimethylamine, and monomethylamine methyltransferases) all have the unusual, ribosomally incorporated amino acid pyrrolysine at the active site. All act in systems in which a methyl group is transferred to the corrinoid protein to create methylcobalamin, from which the methyl group is later transferred elsewhere.
ReferencesDR PFAM; PF02310; B12-binding DR PFAM; PF02607; B12-binding_2