HMM Summary Page: TIGR02361

Functiondihydroxyacetone kinase
Gene SymboldhaK
Trusted Cutoff574.95
Domain Trusted Cutoff574.95
Noise Cutoff448.75
Domain Noise Cutoff448.75
Isology Typeequivalog
EC Number2.7.1.29
HMM Length583
AuthorHaft DH
Entry DateOct 28 2004 9:57AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis family consists of examples of the form of dihydroxyacetone kinase (also called glycerone kinase) that uses ATP ( as the phosphate donor, rather than a phosphoprotein as in E. coli. This form is composed of a single chain with separable domains homologous to the K and L subunits of the E. coli enzyme, and is found in yeasts and other eukaryotes and in some bacteria, including Citrobacter freundii. The member from tomato has been shown to phosphorylate dihydroxyacetone, 3,4-dihydroxy-2-butanone, and some other aldoses and ketoses (PMID:11985845).
ReferencesRN [1] RM 12966101 RT Crystal structure of the Citrobacter freundii dihydroxyacetone kinase reveals an eight-stranded alpha-helical barrel ATP-binding domain. RA Siebold C, Arnold I, Garcia-Alles LF, Baumann U, Erni B. RL J Biol Chem. 2003 Nov 28;278(48):48236-44. RN [2] RM 11985845 RT A tomato enzyme catalyzing the phosphorylation of 3,4-dihydroxy-2-butanone. RA Herz S, Kis K, Bacher A, Rohdich F. RL Phytochemistry. 2002 May;60(1):3-11.