HMM Summary Page: TIGR02359

Functionenergy coupling factor transporter S component ThiW
Gene SymbolthiW
Trusted Cutoff84.35
Domain Trusted Cutoff84.35
Noise Cutoff33.75
Domain Noise Cutoff33.75
Isology Typeequivalog
HMM Length160
Mainrole CategoryTransport and binding proteins
Subrole CategoryOther
Gene Ontology TermGO:0009228: thiamine biosynthetic process biological_process
AuthorHaft DH
Entry DateOct 20 2004 4:52PM
Last ModifiedMar 14 2014 11:28AM
CommentLevels of thiamine pyrophosphate (TPP) or thiamine regulate transcription or translation of a number of thiamine biosynthesis, salvage, or transport genes in a wide range of prokaryotes. The mechanism involves direct binding, with no protein involved,to a structural element called THI found in the untranslated upstream region of thiamine metabolism gene operons. This element is called a riboswitch and is seen also for other metabolites such as FMN and glycine. This protein family consists of proteins identified in operons controlled by the THI riboswitch and designated ThiW. The hydrophobic nature of this protein and reconstructed metabolic background suggests that this protein acts in transport of a thiazole precursor of thiamine.
ReferencesRM 12376536 RT Comparative genomics of thiamin biosynthesis in procaryotes. New genes and regulatory mechanisms. RA Rodionov DA, Vitreschak AG, Mironov AA, Gelfand MS. RL J Biol Chem. 2002 Dec 13;277(50):48949-59. RN [2] RM PMID:18931129 RT A novel class of modular transporters for vitamins in prokaryotes. RA Rodionov DA, Hebbeln P, Eudes A, ter Beek J, Rodionova IA, Erkens GB, Slotboom DJ, Gelfand MS, Osterman AL, Hanson AD, Eitinger T RL J Bacteriol. 2009 Jan;191(1):42-51. doi: 10.1128/JB.01208-08.
Genome PropertyGenProp1094: energy-coupling factor transporters (HMM)