HMM Summary Page: TIGR02358

Functionputative hydroxymethylpyrimidine transporter CytX
Gene SymbolcytX
Trusted Cutoff309.85
Domain Trusted Cutoff309.85
Noise Cutoff170.55
Domain Noise Cutoff170.55
Isology Typehypoth_equivalog
HMM Length386
Mainrole CategoryTransport and binding proteins
Subrole CategoryNucleosides, purines and pyrimidines
AuthorHaft DH
Entry DateOct 19 2004 3:08PM
Last ModifiedMay 25 2011 6:51PM
CommentOn the basis of a phylogenomic study of thiamine biosythetic, salvage, and transporter genes and a highly conserved RNA element THI, this protein family has been identified as a probable transporter of hydroxymethylpyrimidine (HMP), the phosphorylated (by ThiD) form of which gets joined (by ThiE) to hydroxyethylthiazole phosphate to make thiamine phosphate.
ReferencesRM 12376536 RT Comparative genomics of thiamin biosynthesis in procaryotes. New genes and regulatory mechanisms. RA Rodionov DA, Vitreschak AG, Mironov AA, Gelfand MS. RL J Biol Chem. 2002 Dec 13;277(50):48949-59.