| Accession | TIGR02357 |
| Name | ECF_ThiT_YuaJ |
| Function | energy-coupled thiamine transporter ThiT |
| Gene Symbol | thiT |
| Trusted Cutoff | 108.45 |
| Domain Trusted Cutoff | 108.45 |
| Noise Cutoff | 61.35 |
| Domain Noise Cutoff | 61.35 |
| Isology Type | equivalog |
| HMM Length | 183 |
| Mainrole Category | Transport and binding proteins |
| Subrole Category | Other |
| Gene Ontology Term | GO:0015234: thiamine transmembrane transporter activity molecular_function |
| | GO:0015888: thiamine transport biological_process |
| Author | Haft DH |
| Entry Date | Oct 18 2004 5:25PM |
| Last Modified | Mar 14 2014 1:15PM |
| Comment | Members of this protein family have been assigned as thiamine transporters by a phylogenomic analysis of families of genes regulated by the THI element, a broadly conserved RNA secondary structure element through which thiamine pyrophosphate (TPP) levels can regulate transcription of many genes related to thiamine transport, salvage, and de novo biosynthesis. Species with this protein always lack the ThiBPQ ABC transporter. In some species (e.g. Steptococcus mutans and Streptoccus pyogenes), yuaJ is the only THI-regulated gene. Evidence from Bacillus cereus indicated thiamine uptake is coupled to proton translocation. However, a more recent comprehensive study of energy-coupled factor (ECF) transport suggests this protein is the S (subtrate capture) component of an ECF system, meaning it is energized by ATP. Previously YuaJ, but renamed ThiT. |
| References | RM 12376536
RT Comparative genomics of thiamin biosynthesis in procaryotes. New genes and regulatory mechanisms.
RA Rodionov DA, Vitreschak AG, Mironov AA, Gelfand MS.
RL J Biol Chem. 2002 Dec 13;277(50):48949-59.
RN [2]
RM PMID:18931129
RT A novel class of modular transporters for vitamins in prokaryotes.
RA Rodionov DA, Hebbeln P, Eudes A, ter Beek J, Rodionova IA, Erkens GB, Slotboom DJ, Gelfand MS, Osterman AL, Hanson AD, Eitinger T
RL J Bacteriol. 2009 Jan;191(1):42-51. doi: 10.1128/JB.01208-08. |
| Genome Property | GenProp1094: energy-coupling factor transporters (HMM) |
