HMM Summary Page: TIGR02357

Functionenergy-coupled thiamine transporter ThiT
Gene SymbolthiT
Trusted Cutoff108.45
Domain Trusted Cutoff108.45
Noise Cutoff61.35
Domain Noise Cutoff61.35
Isology Typeequivalog
HMM Length183
Mainrole CategoryTransport and binding proteins
Subrole CategoryOther
Gene Ontology TermGO:0015234: thiamine transmembrane transporter activity molecular_function
GO:0015888: thiamine transport biological_process
AuthorHaft DH
Entry DateOct 18 2004 5:25PM
Last ModifiedMar 14 2014 1:15PM
CommentMembers of this protein family have been assigned as thiamine transporters by a phylogenomic analysis of families of genes regulated by the THI element, a broadly conserved RNA secondary structure element through which thiamine pyrophosphate (TPP) levels can regulate transcription of many genes related to thiamine transport, salvage, and de novo biosynthesis. Species with this protein always lack the ThiBPQ ABC transporter. In some species (e.g. Steptococcus mutans and Streptoccus pyogenes), yuaJ is the only THI-regulated gene. Evidence from Bacillus cereus indicated thiamine uptake is coupled to proton translocation. However, a more recent comprehensive study of energy-coupled factor (ECF) transport suggests this protein is the S (subtrate capture) component of an ECF system, meaning it is energized by ATP. Previously YuaJ, but renamed ThiT.
ReferencesRM 12376536 RT Comparative genomics of thiamin biosynthesis in procaryotes. New genes and regulatory mechanisms. RA Rodionov DA, Vitreschak AG, Mironov AA, Gelfand MS. RL J Biol Chem. 2002 Dec 13;277(50):48949-59. RN [2] RM PMID:18931129 RT A novel class of modular transporters for vitamins in prokaryotes. RA Rodionov DA, Hebbeln P, Eudes A, ter Beek J, Rodionova IA, Erkens GB, Slotboom DJ, Gelfand MS, Osterman AL, Hanson AD, Eitinger T RL J Bacteriol. 2009 Jan;191(1):42-51. doi: 10.1128/JB.01208-08.
Genome PropertyGenProp1094: energy-coupling factor transporters (HMM)