HMM Summary Page: TIGR02355

Functionmolybdopterin synthase sulfurylase MoeB
Gene SymbolmoeB
Trusted Cutoff376.55
Domain Trusted Cutoff376.55
Noise Cutoff340.15
Domain Noise Cutoff340.15
Isology Typeequivalog
HMM Length240
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryMolybdopterin
AuthorHaft DH
Entry DateOct 14 2004 11:18AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model describes the molybdopterin biosynthesis protein MoeB in E. coli and related species. The enzyme covalently modifies the molybdopterin synthase MoaD by sulfurylation. This enzyme is closely related to ThiF, a thiamine biosynthesis enzyme that modifies ThiS by an analogous adenylation. Both MoeB and ThiF belong to the HesA/MoeB/ThiF family (PF00899).
ReferencesRN [1] RM 12234097 RT Differential effects of a molybdopterin synthase sulfurylase (moeB) mutation on Escherichia coli molybdoenzyme maturation. RA Sambasivarao D, Turner RJ, Bilous PT, Rothery RA, Shaw G, Weiner JH. RL Biochem Cell Biol. 2002;80(4):435-43.