HMM Summary Page: TIGR02354

Functionthiamine biosynthesis protein ThiF
Gene SymbolthiF
Trusted Cutoff152.20
Domain Trusted Cutoff152.20
Noise Cutoff114.60
Domain Noise Cutoff114.60
Isology Typeequivalog
HMM Length200
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryThiamine
Gene Ontology TermGO:0009228: thiamine biosynthetic process biological_process
GO:0016779: nucleotidyltransferase activity molecular_function
AuthorHaft DH
Entry DateOct 13 2004 4:20PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of the HesA/MoeB/ThiF family of proteins (PF00899) include a number of members encoded in the midst of thiamine biosynthetic operons. This mix of known and putative ThiF proteins shows a deep split in phylogenetic trees, with one the E. coli ThiF and the E. coli MoeB proteins seemingly more closely related than E. coli ThiF and Campylobacter (for example) ThiF. This model represents the divergent clade of putative ThiF proteins such found in Campylobacter.
ReferencesDR PFAM; PF00899; ThiF/MoeB/HesA family
Genome PropertyGenProp0250: thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly (HMM)