HMM Summary Page: TIGR02350

Functionchaperone protein DnaK
Gene SymboldnaK
Trusted Cutoff822.55
Domain Trusted Cutoff822.55
Noise Cutoff641.45
Domain Noise Cutoff641.45
Isology Typeequivalog
HMM Length596
Mainrole CategoryProtein fate
Subrole CategoryProtein folding and stabilization
Gene Ontology TermGO:0005524: ATP binding molecular_function
GO:0006457: protein folding biological_process
GO:0006950: response to stress biological_process
GO:0016887: ATPase activity molecular_function
GO:0051082: unfolded protein binding molecular_function
AuthorHaft DH
Entry DateOct 8 2004 2:03PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family are the chaperone DnaK, of the DnaK-DnaJ-GrpE chaperone system. All members of the seed alignment were taken from completely sequenced bacterial or archaeal genomes and (except for Mycoplasma sequence) found clustered with other genes of this systems. This model excludes DnaK homologs that are not DnaK itself, such as the heat shock cognate protein HscA (TIGR01991). However, it is not designed to distinguish among DnaK paralogs in eukaryotes. Note that a number of dnaK genes have shadow ORFs in the same reverse (relative to dnaK) reading frame, a few of which have been assigned glutamate dehydrogenase activity. The significance of this observation is unclear; lengths of such shadow ORFs are highly variable as if the presumptive protein product is not conserved.
ReferencesDR PFAM; PF00012; DR HAMAP; MF_00332; 565 of 584
Genome PropertyGenProp0244: chaperone system: DnaK-DnaJ-GrpE (HMM)
GenProp0799: bacterial core gene set, exactly 1 per genome (HMM)