HMM Summary Page: TIGR02339

Functionthermosome, various subunits, archaeal
Trusted Cutoff671.10
Domain Trusted Cutoff671.10
Noise Cutoff539.80
Domain Noise Cutoff539.80
Isology Typesubfamily
HMM Length521
Mainrole CategoryProtein fate
Subrole CategoryProtein folding and stabilization
AuthorHaft DH
Entry DateOct 6 2004 10:38AM
Last ModifiedFeb 14 2011 3:27PM
CommentThermosome is the name given to the archaeal rather than eukaryotic form of the group II chaperonin (counterpart to the group I chaperonin, GroEL/GroES, in bacterial), a torroidal, ATP-dependent molecular chaperone that assists in the folding or refolding of nascent or denatured proteins. Various homologous subunits, one to five per archaeal genome, may be designated alpha, beta, etc., but phylogenetic analysis does not show distinct alpha subunit and beta subunit lineages traceable to ancient paralogs.
ReferencesRN [1] RM 12796498 RT Coexistence of group I and group II chaperonins in the archaeon Methanosarcina mazei. RA Klunker D, Haas B, Hirtreiter A, Figueiredo L, Naylor DJ, Pfeifer G, Muller V, Deppenmeier U, Gottschalk G, Hartl FU, Hayer-Hartl M. RL J Biol Chem. 2003 Aug 29;278(35):33256-67.
Genome PropertyGenProp0246: chaperone system: thermosome/prefoldin (HMM)