HMM Summary Page: TIGR02335

Functionphosphonoacetate hydrolase
Gene SymbolphnA
Trusted Cutoff407.55
Domain Trusted Cutoff407.55
Noise Cutoff84.50
Domain Noise Cutoff84.50
Isology Typeequivalog
EC Number3.11.1.2
HMM Length408
Gene Ontology TermGO:0019636: phosphonoacetate metabolic process biological_process
GO:0047400: phosphonoacetate hydrolase activity molecular_function
AuthorHaft DH
Entry DateOct 1 2004 2:37PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis family consists of examples of phosphonoacetate hydrolase, an enzyme specific for the cleavage of the C-P bond in phosphonoacetate. Phosphonates are organic compounds with a direct C-P bond that is far less labile that the C-O-P bonds of phosphate attachment sites. Phosphonates may be degraded for phosphorus and energy by broad spectrum C-P lyase encoded by large operon or by specific enzymes for some of the more common phosphonates in nature. This family represents an enzyme from the latter category. It may be found encoded near genes for phosphonate transport and for pther specific phosphonatases.
ReferencesRM 9300819 RT Cloning of the phosphonoacetate hydrolase gene from Pseudomonas fluorescens 23F encoding a new type of carbon-phosphorus bond cleaving enzyme and its expression in Escherichia coli and Pseudomonas putida. RA Kulakova AN, Kulakov LA, Quinn JP. RL Gene. 1997 Aug 11;195(1):49-53.
Genome PropertyGenProp0713: 2-aminoethylphosphonate catabolism via phosphonoacetate (HMM)