HMM Summary Page: TIGR02334

Functionprobable AcnD-accessory protein PrpF
Gene SymbolprpF
Trusted Cutoff440.55
Domain Trusted Cutoff440.55
Noise Cutoff415.90
Domain Noise Cutoff415.90
Isology Typeequivalog
HMM Length390
Gene Ontology TermGO:0019629: propionate catabolic process, 2-methylcitrate cycle biological_process
AuthorHaft DH
Entry DateOct 1 2004 12:45PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe 2-methylcitrate cycle is one of at least five degradation pathways for propionate via propionyl-CoA. Degradation of propionate toward pyruvate consumes oxaloacetate and releases succinate. Oxidation of succinate back into oxaloacetate by the TCA cycle makes the 2-methylcitrate pathway a cycle. This family consists of PrpF, an incompletely characterized protein that appears to be an essential accessory protein for the Fe/S-dependent 2-methylisocitrate dehydratase AcnD (TIGR02333). This protein is related to but distinct from FldA (part of Pfam family PF04303), a putative fluorene degradation protein of Sphingomonas sp. LB126.
ReferencesDR PFAM; PF04303; DUF453
Genome PropertyGenProp0240: propionyl-CoA catabolism via methylcitric acid (HMM)