Accession | TIGR02330 |
Name | prpD |
Function | 2-methylcitrate dehydratase |
Gene Symbol | prpD |
Trusted Cutoff | 458.00 |
Domain Trusted Cutoff | 458.00 |
Noise Cutoff | 330.70 |
Domain Noise Cutoff | 330.70 |
Isology Type | equivalog |
EC Number | 4.2.1.79 |
HMM Length | 468 |
Gene Ontology Term | GO:0019629: propionate catabolic process, 2-methylcitrate cycle biological_process |
| GO:0047547: 2-methylcitrate dehydratase activity molecular_function |
Author | Haft DH |
Entry Date | Sep 30 2004 1:41PM |
Last Modified | Feb 14 2011 3:27PM |
Comment | Members of this family are bacterial proteins known or predicted to act as 2-methylcitrate dehydratase, an enzyme involved in the methylcitrate cycle of propionate catabolism. A related clade of archaeal proteins that may or may not be functionally equivalent is reserved for a future model and is excluded from this family. The PrpD enzyme of E. coli is responsible for the minor aconitase activity (AcnC) not accounted for by AcnA and AcnB. |
References | RN [1]
RM 12473114
RT Oxidation of propionate to pyruvate in Escherichia coli. Involvement of methylcitrate dehydratase and aconitase.
RA Brock M, Maerker C, Schutz A, Volker U, Buckel W.
RL Eur J Biochem. 2002 Dec;269(24):6184-94.
RN [2]
RM 11782506
RT AcnC of Escherichia coli is a 2-methylcitrate dehydratase (PrpD) that can use citrate and isocitrate as substrates.
RA Blank L, Green J, Guest JR.
RL Microbiology. 2002 Jan;148(Pt 1):133-46. |
Genome Property | GenProp0240: propionyl-CoA catabolism via methylcitric acid (HMM) |