HMM Summary Page: TIGR02330

Function2-methylcitrate dehydratase
Gene SymbolprpD
Trusted Cutoff458.00
Domain Trusted Cutoff458.00
Noise Cutoff330.70
Domain Noise Cutoff330.70
Isology Typeequivalog
EC Number4.2.1.79
HMM Length468
Gene Ontology TermGO:0019629: propionate catabolic process, 2-methylcitrate cycle biological_process
GO:0047547: 2-methylcitrate dehydratase activity molecular_function
AuthorHaft DH
Entry DateSep 30 2004 1:41PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family are bacterial proteins known or predicted to act as 2-methylcitrate dehydratase, an enzyme involved in the methylcitrate cycle of propionate catabolism. A related clade of archaeal proteins that may or may not be functionally equivalent is reserved for a future model and is excluded from this family. The PrpD enzyme of E. coli is responsible for the minor aconitase activity (AcnC) not accounted for by AcnA and AcnB.
ReferencesRN [1] RM 12473114 RT Oxidation of propionate to pyruvate in Escherichia coli. Involvement of methylcitrate dehydratase and aconitase. RA Brock M, Maerker C, Schutz A, Volker U, Buckel W. RL Eur J Biochem. 2002 Dec;269(24):6184-94. RN [2] RM 11782506 RT AcnC of Escherichia coli is a 2-methylcitrate dehydratase (PrpD) that can use citrate and isocitrate as substrates. RA Blank L, Green J, Guest JR. RL Microbiology. 2002 Jan;148(Pt 1):133-46.
Genome PropertyGenProp0240: propionyl-CoA catabolism via methylcitric acid (HMM)