| Accession | TIGR02326 |
| Name | transamin_PhnW |
| Function | 2-aminoethylphosphonate--pyruvate transaminase |
| Gene Symbol | phnW |
| Trusted Cutoff | 400.80 |
| Domain Trusted Cutoff | 400.80 |
| Noise Cutoff | 339.35 |
| Domain Noise Cutoff | 339.35 |
| Isology Type | equivalog |
| EC Number | 2.6.1.37 |
| HMM Length | 363 |
| Mainrole Category | Central intermediary metabolism |
| Subrole Category | Phosphorus compounds |
| Author | Haft DH |
| Entry Date | Sep 29 2004 2:21PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Members of this family are 2-aminoethylphosphonate--pyruvate transaminase. This enzyme acts on the most common type of naturally occurring phosphonate. It interconverts 2-aminoethylphosphonate plus pyruvate with 2-phosphonoacetaldehyde plus alanine. The enzyme phosphonoacetaldehyde hydrolase (EC 3.11.1.1), usually encoded by an adjacent gene, then cleaves the C-P bond of phosphonoacetaldehyde, adding water to yield acetaldehyde plus inorganic phosphate. Species with this pathway generally have an identified phosphonate ABC transporter but do not also have the multisubunit C-P lysase complex as found in Escherichia coli. |
| References |
DR HAMAP; MF_01376; 56 of 56 |
| Genome Property | GenProp0238: 2-aminoethylphosphonate catabolism to acetaldehyde (HMM) |
| | GenProp0713: 2-aminoethylphosphonate catabolism via phosphonoacetate (HMM) |
| | GenProp0724: phosphonoacetaldehyde biosynthesis from phosphoenolpyruvate (SUBFAM-EX) |
