HMM Summary Page: TIGR02324

Functionphosphonate C-P lyase system protein PhnL
Gene SymbolphnL
Trusted Cutoff256.30
Domain Trusted Cutoff256.30
Noise Cutoff153.25
Domain Noise Cutoff153.25
Isology Typeequivalog
HMM Length224
Gene Ontology TermGO:0018835: carbon phosphorus lyase activity molecular_function
GO:0019634: organic phosphonate metabolic process biological_process
AuthorHaft DH
Entry DateSep 28 2004 3:09PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family are the PhnL protein of C-P lyase systems for utilization of phosphonates. These systems resemble phosphonatase-based systems in having a three component ABC transporter, where TIGR01097 is the permease, TIGR01098 is the phosphonates binding protein, and TIGR02315 is the ATP-binding cassette (ABC) protein. They differ, however, in having, typically, ten or more additional genes, many of which are believed to form a membrane-associated C-P lysase complex. This protein (PhnL) and the adjacent-encoded PhnK (TIGR02323) resemble transporter ATP-binding proteins but are suggested, based on mutatgenesis studies, to be part of this C-P lyase complex rather than part of a transporter per se.
ReferencesRN [1] RM 8388873 RT Mutational analysis of an Escherichia coli fourteen-gene operon for phosphonate degradation, using TnphoA' elements. RA Metcalf WW, Wanner BL. RL J Bacteriol. 1993 Jun;175(11):3430-42.
Genome PropertyGenProp0232: phosphonates C-P lyase system (HMM)