HMM Summary Page: TIGR02323

Functionphosphonate C-P lyase system protein PhnK
Gene SymbolphnK
Trusted Cutoff302.85
Domain Trusted Cutoff302.85
Noise Cutoff158.50
Domain Noise Cutoff158.50
Isology Typeequivalog
HMM Length239
Mainrole CategoryCentral intermediary metabolism
Subrole CategoryPhosphorus compounds
Gene Ontology TermGO:0018835: carbon phosphorus lyase activity molecular_function
GO:0019634: organic phosphonate metabolic process biological_process
AuthorHaft DH, Selengut J
Entry DateSep 28 2004 1:02PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family are the PhnK protein of C-P lyase systems for utilization of phosphonates. These systems resemble phosphonatase-based systems in having a three component ABC transporter, where TIGR01097 is the permease, TIGR01098 is the phosphonates binding protein, and TIGR02315 is the ATP-binding cassette (ABC) protein. They differ, however, in having, typically, ten or more additional genes, many of which are believed to form a membrane-associated complex. This protein (PhnK) and the adjacent-encoded PhnL resemble transporter ATP-binding proteins but are suggested, based on mutatgenesis studies, to be part of this complex rather than part of a transporter per se.
ReferencesRN [1] RM 8388873 RT Mutational analysis of an Escherichia coli fourteen-gene operon for phosphonate degradation, using TnphoA' elements. RA Metcalf WW, Wanner BL. RL J Bacteriol. 1993 Jun;175(11):3430-42.
Genome PropertyGenProp0232: phosphonates C-P lyase system (HMM)