| Accession | TIGR02322 |
| Name | phosphon_PhnN |
| Function | phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN |
| Gene Symbol | phnN |
| Trusted Cutoff | 156.00 |
| Domain Trusted Cutoff | 156.00 |
| Noise Cutoff | 73.35 |
| Domain Noise Cutoff | 73.35 |
| Isology Type | equivalog |
| HMM Length | 179 |
| Mainrole Category | Central intermediary metabolism |
| Subrole Category | Phosphorus compounds |
| Gene Ontology Term | GO:0003674: molecular_function molecular_function |
| | GO:0019634: organic phosphonate metabolic process biological_process |
| Author | Haft DH |
| Entry Date | Sep 27 2004 5:38PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Members of this family resemble PhnN of phosphonate utilization operons, where different such operons confer the ability to use somewhat different profiles of C-P bond-containing compounds (see PMID:15231805), including phosphites as well as phosphonates. PhnN in E. coli shows considerable homology to guanylate kinases (EC 2.7.4.8), and has actually been shown to act as a ribose 1,5-bisphosphokinase (PRPP forming). This suggests an analogous kinase reaction for phosphonate metabolism, converting 5-phosphoalpha-1-(methylphosphono)ribose to methylphosphono-PRPP. |
| References | RN [1]
RM PMID: 12700258
RT Escherichia coli phnN, encoding ribose 1,5-bisphosphokinase activity (phosphoribosyl diphosphate forming): dual role in phosphonate degradation and NAD biosynthesis pathways.
RA Hove-Jensen B, Rosenkrantz TJ, Haldimann A, Wanner BL.
RL J Bacteriol. 2003 May;185(9):2793-801.
DR HAMAP; MF_00703; 4 of 55 |
| Genome Property | GenProp0232: phosphonates C-P lyase system (HMM) |
