HMM Summary Page: TIGR02319

Functioncarboxyvinyl-carboxyphosphonate phosphorylmutase
Gene SymbolbcpA
Trusted Cutoff420.05
Domain Trusted Cutoff420.05
Noise Cutoff255.20
Domain Noise Cutoff255.20
Isology Typeequivalog
EC Number2.7.8.23
HMM Length294
AuthorHaft DH
Entry DateSep 27 2004 4:38PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis family consists of carboxyvinyl-carboxyphosphonate phosphorylmutase (CPEP phosphonomutase), an unusual enzyme involved in the biosynthesis of the antibiotic bialaphos. So far, it is known only in that pathway and only in Streptomyces hygroscopicus. Some related proteins annotated as being functionally equivalent are likely misannotated examples of methylisocitrate lyase, an enzyme of priopionate utilization.
ReferencesDR SWISSPROT; P11435; Streptomyces hygroscopicus RN [1] RM 2160937 RT Carboxyphosphonoenolpyruvate phosphonomutase, a novel enzyme catalyzing C-P bond formation. RA Hidaka T, Imai S, Hara O, Anzai H, Murakami T, Nagaoka K, Seto H. RL J Bacteriol. 1990 Jun;172(6):3066-72.