HMM Summary Page: TIGR02317

Functionmethylisocitrate lyase
Gene SymbolprpB
Trusted Cutoff354.40
Domain Trusted Cutoff354.40
Noise Cutoff318.80
Domain Noise Cutoff318.80
Isology Typeequivalog
EC Number4.1.3.30
HMM Length285
Gene Ontology TermGO:0019629: propionate catabolic process, 2-methylcitrate cycle biological_process
GO:0046421: methylisocitrate lyase activity molecular_function
AuthorHaft DH
Entry DateSep 27 2004 2:14PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family are methylisocitrate lyase, also called (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase. This enzyme acts in propionate metabolism. It cleaves a carbon-carbon bond to convert 2-methylisocitrate to pyruvate plus succinate. Some members of this family have been annotated, incorrectly it seems, as the related protein carboxyphosphoenolpyruvate phosphomutase, which is involved in synthesizing the antibiotic bialaphos in Streptomyces hygroscopicus.
Genome PropertyGenProp0240: propionyl-CoA catabolism via methylcitric acid (HMM)