HMM Summary Page: TIGR02316

Functionpropionate--CoA ligase
Gene SymbolprpE
Trusted Cutoff827.40
Domain Trusted Cutoff827.40
Noise Cutoff760.80
Domain Noise Cutoff760.80
Isology Typeequivalog
EC Number6.2.1.17
HMM Length628
AuthorHaft DH
Entry DateSep 24 2004 3:32PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis family contains one of three readily separable clades of proteins in the group of acetate and propionate--CoA ligases. Characterized members of this family act on propionate. From propionyl-CoA, there is a cyclic degradation pathway: it is ligated by PrpC to the TCA cycle intermediate oxaloacetate, acted upon further by PrpD and an aconitase, then cleaved by PrpB to pyruvate and the TCA cycle intermediate succinate.