HMM Summary Page: TIGR02307

FunctionRNA ligase, Rnl2 family
Trusted Cutoff197.15
Domain Trusted Cutoff197.15
Noise Cutoff62.35
Domain Noise Cutoff62.35
Isology Typeequivalog
EC Number6.5.1.3
HMM Length326
Mainrole CategoryMobile and extrachromosomal element functions
Subrole CategoryProphage functions
AuthorHaft DH
Entry DateSep 22 2004 2:17PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family ligate (seal breaks in) RNA. Members so far include phage proteins that can counteract a host defense of cleavage of specific tRNA molecules, trypanosome ligases involved in RNA editing, but no prokaryotic host proteins .
ReferencesRN [1] RM 12228725 RT Bacteriophage T4 RNA ligase 2 (gp24.1) exemplifies a family of RNA ligases found in all phylogenetic domains. RA Ho CK, Shuman S. RL Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12709-14.