HMM Summary Page: TIGR02306

FunctionRNA ligase
Trusted Cutoff151.15
Domain Trusted Cutoff151.15
Noise Cutoff49.30
Domain Noise Cutoff49.30
Isology Typeequivalog
EC Number6.5.1.3
HMM Length341
AuthorHaft DH
Entry DateSep 22 2004 1:56PM
Last ModifiedMar 9 2012 2:40PM
CommentThe member of this family from Deinococcus radiodurans, a species that withstands and recovers from extensive radiation or dessication damage, is an apparent RNA ligase. It repairs RNA stand breaks in nicked DNA:RNA and RNA:RNA but not DNA:DNA duplexes. It has adenylyltransferase activity associated with the C-terminal domain. Related proteins also in this family are found in Streptomyces avermitilis MA-4680 and in bacteriophage 44RR2.8t. The phage example is unsurprising since one mechanism of host cell defense against phage is cleavage and inactivation of certain tRNA molecules. A fungal sequence from Neurospora crassa scores between trusted and noise cutofffs and may be similar in function.
ReferencesRM 15333634 RT An RNA Ligase from Deinococcus radiodurans. RA Martins A, Shuman S. RL in press, 2004