HMM Summary Page: TIGR02305

Function4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, N-terminal subunit
Gene SymbolhpaG
Trusted Cutoff228.65
Domain Trusted Cutoff228.65
Noise Cutoff203.25
Domain Noise Cutoff203.25
Isology Typeequivalog_domain
EC Number4.1.1.68
HMM Length205
AuthorSelengut J
Entry DateSep 22 2004 11:32AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model represents one of two subunits/domains of the bifunctional isomerase/decarboxylase involved in 4-hydroxyphenylacetate degradation [1]. In E. coli and some other species this enzyme is encoded by a single polypeptide containing both this domain and the closely related C-terminal domain (TIGR02303). In other species such as Pasteurella multocida these domains are found as two separate proteins (usually as tandem genes). Together, these domains carry out the decarboxylation of 5-oxopent-3-ene-1,2,5-tricarboxylic acid (OPET) to 2-hydroxy-2,4-diene-1,7-dioate (HHDD) and the subsequent isomerization to 2-oxohept-3-ene-1,7-dioate (OHED).
ReferencesRN [1] RM PMID: 11863436 RT The crystal structure of HpcE, a bifunctional decarboxylase/isomerase with a multifunctional fold. RA Tame JR, Namba K, Dodson EJ, Roper DI. RL Biochemistry. 2002 Mar 5;41(9):2982-9.
Genome PropertyGenProp0231: 4-hydroxyphenylacetate degradation (HMM)