HMM Summary Page: TIGR02304

Functionputative adenylate-forming enzyme
Trusted Cutoff251.90
Domain Trusted Cutoff251.90
Noise Cutoff110.70
Domain Noise Cutoff110.70
Isology Typehypoth_equivalog
HMM Length430
AuthorHaft DH
Entry DateSep 21 2004 11:18AM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family form a distinct clade within a larger family of proteins that also includes coenzyme F390 synthetase, an enzyme known in Methanobacterium thermoautotrophicum and a few other methanogenic archaea. That enzyme adenylates coenzyme F420 to F390, a reversible process, during oxygen stress. Other informative homologies include domains of the non-ribosomal peptide synthetases involved in activation by adenylation. The family defined by this model is likely to be of an adenylate-forming enzyme related to but distinct from coenzyme F390 synthetase.
ReferencesRN [1] RM 8550473 RT Coenzyme F390 synthetase from Methanobacterium thermoautotrophicum Marburg belongs to the superfamily of adenylate-forming enzymes. RA Vermeij P, van der Steen RJ, Keltjens JT, Vogels GD, Leisinger T. RL J Bacteriol. 1996 Jan;178(2):505-10.