| Accession | TIGR02299 |
| Name | HpaE |
| Function | 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase |
| Gene Symbol | hpaE |
| Trusted Cutoff | 638.35 |
| Domain Trusted Cutoff | 638.35 |
| Noise Cutoff | 593.45 |
| Domain Noise Cutoff | 593.45 |
| Isology Type | equivalog |
| EC Number | 1.2.1.60 |
| HMM Length | 488 |
| Author | Selengut J |
| Entry Date | Sep 13 2004 11:59AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This model represents the dehydrogenase responsible for the conversion of 5-carboxymethyl-2-hydroxymuconate semialdehyde to 5-carboxymethyl-2-hydroxymuconate (a tricarboxylic acid). This is the step in the degradation of 4-hydroxyphenylacetic acid via homoprotocatechuate following the oxidative opening of the aromatic ring. |
| References | RN [1]
RM PMID: 2194577
RT Nucleotide sequences of the meta-cleavage pathway enzymes 2-hydroxymuconic semialdehyde dehydrogenase and 2-hydroxymuconic semialdehyde hydrolase from Pseudomonas CF600.
RA Nordlund I, Shingler V.
RL Biochim Biophys Acta. 1990 Jun 21;1049(2):227-30. |
| Genome Property | GenProp0231: 4-hydroxyphenylacetate degradation (HMM) |
