HMM Summary Page: TIGR02299

Function5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase
Gene SymbolhpaE
Trusted Cutoff638.35
Domain Trusted Cutoff638.35
Noise Cutoff593.45
Domain Noise Cutoff593.45
Isology Typeequivalog
EC Number1.2.1.60
HMM Length488
AuthorSelengut J
Entry DateSep 13 2004 11:59AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model represents the dehydrogenase responsible for the conversion of 5-carboxymethyl-2-hydroxymuconate semialdehyde to 5-carboxymethyl-2-hydroxymuconate (a tricarboxylic acid). This is the step in the degradation of 4-hydroxyphenylacetic acid via homoprotocatechuate following the oxidative opening of the aromatic ring.
ReferencesRN [1] RM PMID: 2194577 RT Nucleotide sequences of the meta-cleavage pathway enzymes 2-hydroxymuconic semialdehyde dehydrogenase and 2-hydroxymuconic semialdehyde hydrolase from Pseudomonas CF600. RA Nordlund I, Shingler V. RL Biochim Biophys Acta. 1990 Jun 21;1049(2):227-30.
Genome PropertyGenProp0231: 4-hydroxyphenylacetate degradation (HMM)