| Accession | TIGR02296 |
| Name | HpaC |
| Function | 4-hydroxyphenylacetate 3-monooxygenase, reductase component |
| Gene Symbol | hpaC |
| Trusted Cutoff | 205.95 |
| Domain Trusted Cutoff | 205.95 |
| Noise Cutoff | 178.90 |
| Domain Noise Cutoff | 178.90 |
| Isology Type | equivalog |
| EC Number | 1.14.14.9 |
| HMM Length | 154 |
| Gene Ontology Term | GO:0018660: 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity molecular_function |
| Author | Selengut J |
| Entry Date | Sep 10 2004 9:33AM |
| Last Modified | May 22 2012 12:18PM |
| Comment | This model identifies the reductase component (HpaC) of 4-hydroxyphenylacetate 3-monooxygenase [1]. This enzyme catalyzes the first step (hydroxylation at the 3-position) in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate. 4-hydroxyphenylacetate arises from the degradation of tyrosine.
These reductases catalyze the reduction of free flavins by NADPH. The flavin is then utilized by the large subunit of the monooxygenase. |
| References | RN [1]
RM PMID: 8077235
RT Molecular characterization of 4-hydroxyphenylacetate 3-hydroxylase of Escherichia coli. A two-protein component enzyme.
RA Prieto MA, Garcia JL.
RL J Biol Chem. 1994 Sep 9;269(36):22823-9. |
| Genome Property | GenProp0231: 4-hydroxyphenylacetate degradation (HMM) |
