| Accession | TIGR02295 |
| Name | HpaD |
| Function | 3,4-dihydroxyphenylacetate 2,3-dioxygenase |
| Gene Symbol | hpaD |
| Trusted Cutoff | 321.40 |
| Domain Trusted Cutoff | 321.40 |
| Noise Cutoff | 264.70 |
| Domain Noise Cutoff | 264.70 |
| Isology Type | equivalog |
| EC Number | 1.13.11.15 |
| HMM Length | 298 |
| Author | Selengut J |
| Entry Date | Sep 9 2004 3:29PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This enzyme catalyzes the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate. 4-hydroxyphenylacetate arises from the degradation of tyrosine. The substrate, 3,4-dihydroxyphenylacetate (homoprotocatechuate) arises from the action of a hydroxylase on 4-hydroxyphenylacetate. The aromatic ring is opened by this dioxygenase exo to the 3,4-diol resulting in 2-hydroxy-5-carboxymethylmuconate semialdehyde.
The enzyme from Bacillus brevis contains manganese [1]. |
| References | RN [1]
RM PMID: 6270137
RT 3,4-Dihydroxyphenylacetate 2,3-dioxygenase. A manganese(II) dioxygenase from Bacillus brevis.
RA Que L Jr, Widom J, Crawford RL.
RL J Biol Chem. 1981 Nov 10;256(21):10941-4. |
| Genome Property | GenProp0231: 4-hydroxyphenylacetate degradation (HMM) |
