HMM Summary Page: TIGR02295

Function3,4-dihydroxyphenylacetate 2,3-dioxygenase
Gene SymbolhpaD
Trusted Cutoff321.40
Domain Trusted Cutoff321.40
Noise Cutoff264.70
Domain Noise Cutoff264.70
Isology Typeequivalog
EC Number1.13.11.15
HMM Length298
AuthorSelengut J
Entry DateSep 9 2004 3:29PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis enzyme catalyzes the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate. 4-hydroxyphenylacetate arises from the degradation of tyrosine. The substrate, 3,4-dihydroxyphenylacetate (homoprotocatechuate) arises from the action of a hydroxylase on 4-hydroxyphenylacetate. The aromatic ring is opened by this dioxygenase exo to the 3,4-diol resulting in 2-hydroxy-5-carboxymethylmuconate semialdehyde. The enzyme from Bacillus brevis contains manganese [1].
ReferencesRN [1] RM PMID: 6270137 RT 3,4-Dihydroxyphenylacetate 2,3-dioxygenase. A manganese(II) dioxygenase from Bacillus brevis. RA Que L Jr, Widom J, Crawford RL. RL J Biol Chem. 1981 Nov 10;256(21):10941-4.
Genome PropertyGenProp0231: 4-hydroxyphenylacetate degradation (HMM)