| Accession | TIGR02294 |
| Name | nickel_nikA |
| Function | nickel ABC transporter, nickel/metallophore periplasmic binding protein |
| Gene Symbol | nikA |
| Trusted Cutoff | 393.00 |
| Domain Trusted Cutoff | 393.00 |
| Noise Cutoff | 282.20 |
| Domain Noise Cutoff | 282.20 |
| Isology Type | equivalog |
| HMM Length | 501 |
| Mainrole Category | Transport and binding proteins |
| Subrole Category | Cations and iron carrying compounds |
| Gene Ontology Term | GO:0015413: nickel-transporting ATPase activity molecular_function |
| | GO:0015675: nickel cation transport biological_process |
| | GO:0016151: nickel cation binding molecular_function |
| | GO:0030288: outer membrane-bounded periplasmic space cellular_component |
| | GO:0031362: anchored to external side of plasma membrane cellular_component |
| | GO:0055052: ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing cellular_component |
| Author | Haft DH |
| Entry Date | Sep 9 2004 9:19AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Members of this family are periplasmic nickel-binding proteins of nickel ABC transporters. Most appear to be lipoproteins. This protein was previously (circa 2003) thought to mediate binding to nickel through water molecules, but is now thought to involve a chelating organic molecule, perhaps butane-1,2,4-tricarboxylate, acting as a metallophore. |
| References | RN [1]
RM PMID:18759453
RT Structural characterization of a putative endogenous metal chelator in the periplasmic nickel transporter NikA.
RA Cherrier MV, Cavazza C, Bochot C, Lemaire D, Fontecilla-Camps JC
RL Biochemistry. 2008 Sep 23;47(38):9937-43. Epub 2008 Aug 30. |
| Genome Property | GenProp0494: nickel import ABC transporter (HMM) |
