HMM Summary Page: TIGR02294

Functionnickel ABC transporter, nickel/metallophore periplasmic binding protein
Gene SymbolnikA
Trusted Cutoff393.00
Domain Trusted Cutoff393.00
Noise Cutoff282.20
Domain Noise Cutoff282.20
Isology Typeequivalog
HMM Length501
Mainrole CategoryTransport and binding proteins
Subrole CategoryCations and iron carrying compounds
Gene Ontology TermGO:0015413: nickel-transporting ATPase activity molecular_function
GO:0015675: nickel cation transport biological_process
GO:0016151: nickel cation binding molecular_function
GO:0030288: outer membrane-bounded periplasmic space cellular_component
GO:0031362: anchored to external side of plasma membrane cellular_component
GO:0055052: ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing cellular_component
AuthorHaft DH
Entry DateSep 9 2004 9:19AM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family are periplasmic nickel-binding proteins of nickel ABC transporters. Most appear to be lipoproteins. This protein was previously (circa 2003) thought to mediate binding to nickel through water molecules, but is now thought to involve a chelating organic molecule, perhaps butane-1,2,4-tricarboxylate, acting as a metallophore.
ReferencesRN [1] RM PMID:18759453 RT Structural characterization of a putative endogenous metal chelator in the periplasmic nickel transporter NikA. RA Cherrier MV, Cavazza C, Bochot C, Lemaire D, Fontecilla-Camps JC RL Biochemistry. 2008 Sep 23;47(38):9937-43. Epub 2008 Aug 30.
Genome PropertyGenProp0494: nickel import ABC transporter (HMM)