HMM Summary Page: TIGR02288

Functionphenylacetic acid degradation protein paaN
Gene SymbolpaaN
Trusted Cutoff578.75
Domain Trusted Cutoff578.75
Noise Cutoff271.80
Domain Noise Cutoff271.80
Isology Typeequivalog
HMM Length551
Gene Ontology TermGO:0010124: phenylacetate catabolic process biological_process
AuthorSelengut J
Entry DateSep 2 2004 3:52PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis enzyme is proposed to act in the ring-opening step of phenylacetic acid degradation [1] which follows ligation of the acid with coenzyme A (by PaaF) and hydroxylation by a multicomponent non-heme iron hydroxylase complex (PaaGHIJK). Gene symbols have been standardized in [2]. This enzyme is related to aldehyde dehydrogenases and has a domain which is a member of the PF00171 family. This family includes sequences from Burkholderia, Bordetella, Streptomyces. Other PaaN enzymes are represented by a separate model, TIGR02278.
ReferencesRN [1] RM PMID: 11260461 RT The phenylacetyl-CoA catabolon: a complex catabolic unit with broad biotechnological applications. RA Luengo JM, Garcia JL, Olivera ER. RL Mol Microbiol. 2001 Mar;39(6):1434-42. RN [2] RM PMID: 10766858 RT Transcriptional regulation of the divergent paa catabolic operons for phenylacetic acid degradation in Escherichia coli. RA Ferrandez A, Garcia JL, Diaz E. RL J Biol Chem. 2000 Apr 21;275(16):12214-22.
Genome PropertyGenProp0210: phenylacetic acid catabolism (HMM)