HMM Summary Page: TIGR02281

Functionclan AA aspartic protease, TIGR02281 family
Trusted Cutoff57.95
Domain Trusted Cutoff57.95
Noise Cutoff40.45
Domain Noise Cutoff40.45
Isology Typesubfamily
EC Number3.4.23.-
HMM Length121
Mainrole CategoryProtein fate
Subrole CategoryDegradation of proteins, peptides, and glycopeptides
Gene Ontology TermGO:0004190: aspartic-type endopeptidase activity molecular_function
GO:0008150: biological_process biological_process
AuthorHaft DH
Entry DateAug 31 2004 3:26PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis family consists of predicted aspartic proteases, typically from 180 to 230 amino acids in length, in MEROPS clan AA. This model describes the well-conserved 121-residue C-terminal region. The poorly conserved, variable length N-terminal region usually contains a predicted transmembrane helix. Sequences in the seed alignment and those scoring above the trusted cutoff are Proteobacterial; homologs scroing between trusted and noise are found in Pyrobaculum aerophilum str. IM2 (archaeal), Pirellula sp. (Planctomycetes), and Nostoc sp. PCC 7120 (Cyanobacteria).
ReferencesRN [1] RM PMID:19173708 RT Bioinformatic flowchart and database to investigate the origins and diversity of clan AA peptidases. RA Llorens C, Futami R, Renaud G, Moya A RL Biol Direct. 2009 Jan 27;4:3.