HMM Summary Page: TIGR02278

Functionphenylacetic acid degradation protein paaN
Gene SymbolpaaN
Trusted Cutoff562.80
Domain Trusted Cutoff562.80
Noise Cutoff232.25
Domain Noise Cutoff232.25
Isology Typeequivalog
HMM Length664
AuthorSelengut J
Entry DateAug 31 2004 9:26AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis enzyme is proposed to act in the ring-opening step of phenylacetic acid degradation [1] which follows ligation of the acid with coenzyme A (by PaaF) and hydroxylation by a multicomponent non-heme iron hydroxylase complex (PaaGHIJK). Gene symbols have been standardized in [2]. This enzyme is related to aldehyde dehydrogenases and has domains which are members of the PF00171 and PF01575 families. This family includes paaN genes from Pseudomonas, Sinorhizobium, Rhodopseudomonas, Escherichia, Deinococcus and Corynebacterium. Another homology family (TIGR02288) includes several other species.
ReferencesRN [1] RM PMID: 9748275 RT Catabolism of phenylacetic acid in Escherichia coli. Characterization of a new aerobic hybrid pathway. RA Ferrandez A, Minambres B, Garcia B, Olivera ER, Luengo JM, Garcia JL, Diaz E. RL J Biol Chem. 1998 Oct 2;273(40):25974-86. RN [2] RM PMID: 11260461 RT The phenylacetyl-CoA catabolon: a complex catabolic unit with broad biotechnological applications. RA Luengo JM, Garcia JL, Olivera ER. RL Mol Microbiol. 2001 Mar;39(6):1434-42.
Genome PropertyGenProp0210: phenylacetic acid catabolism (HMM)