HMM Summary Page: TIGR02277

Functionphenylacetic acid degradation operon negative regulatory protein PaaX
Gene SymbolpaaX
Trusted Cutoff264.55
Domain Trusted Cutoff264.55
Noise Cutoff216.80
Domain Noise Cutoff216.80
Isology Typeequivalog
HMM Length279
Mainrole CategoryRegulatory functions
Subrole CategoryDNA interactions
Gene Ontology TermGO:0003700: sequence-specific DNA binding transcription factor activity molecular_function
GO:0006355: regulation of transcription, DNA-dependent biological_process
AuthorSelengut J
Entry DateAug 30 2004 4:00PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis transcriptional regulator is always found in association with operons believed to be involved in the degradation of phenylacetic acid [1]. The gene product has been shown to bind to the promoter sites and repress their transcription [2].
ReferencesRN [1] RM PMID: 11260461 RT The phenylacetyl-CoA catabolon: a complex catabolic unit with broad biotechnological applications. RA Luengo JM, Garcia JL, Olivera ER. RL Mol Microbiol. 2001 Mar;39(6):1434-42. RN [2] RM PMID: 10766858 RT Transcriptional regulation of the divergent paa catabolic operons for phenylacetic acid degradation in Escherichia coli. RA Ferrandez A, Garcia JL, Diaz E. RL J Biol Chem. 2000 Apr 21;275(16):12214-22.
Genome PropertyGenProp0210: phenylacetic acid catabolism (HMM)