HMM Summary Page: TIGR02272

Functiongentisate 1,2-dioxygenase
Gene SymbolgtdA
Trusted Cutoff442.10
Domain Trusted Cutoff442.10
Noise Cutoff225.95
Domain Noise Cutoff225.95
Isology Typeequivalog
EC Number1.13.11.4
HMM Length336
AuthorHaft DH
Entry DateAug 26 2004 2:34PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis family consists of gentisate 1,2-dioxygenases. This ring-opening enzyme acts in salicylate degradation that goes via gentisate rather than via catechol. It converts gentisate to maleylpyruvate. Some putative gentisate 1,2-dioxygenases are excluded by a relatively high trusted cutoff score because they are too closely related to known examples of 1-hydroxy-2-naphthoate dioxygenase. Therefore some homologs may be bona fide gentisate 1,2-dioxygenases even if they score below the given cutoffs.
ReferencesDR EXPERIMENTAL; GB|BAA23262.1; Nocardioides sp. DR EXPERIMENTAL; GB|AAD49427.1; Pseudomonas alcaligenes