HMM Summary Page: TIGR02253

FunctionHAD hydrolase, TIGR02253 family
Trusted Cutoff169.75
Domain Trusted Cutoff169.75
Noise Cutoff148.70
Domain Noise Cutoff148.70
Isology Typesubfamily
HMM Length221
AuthorSelengut J
Entry DateAug 3 2004 10:30AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis family of sequences from archaea and metazoans includes the human uncharacterized protein CTE7. Pyrococcus species appear to have three different forms of this enzyme, so it is unclear whether all members of this family have the same function. This family is a member of the haloacid dehalogenase (HAD) superfamily of hydrolases which are characterized by three conserved sequence motifs [1]. By virtue of an alpha helical domain in-between the first and second conserved motif, this family is a member of subfamily IA (TIGR01549).
ReferencesRN [1] RM PMID: 7966317 RT Computer analysis of bacterial haloacid dehalogenases defines a large superfamily of hydrolases with diverse specificity. Application of an iterative approach to database search. RA Koonin EV, Tatusov RL. RL J Mol Biol 1994 Nov 18;244(1):125-32