HMM Summary Page: TIGR02238

Functionmeiotic recombinase Dmc1
Gene SymbolDMC1
Trusted Cutoff447.70
Domain Trusted Cutoff447.70
Noise Cutoff443.55
Domain Noise Cutoff443.55
Isology Typeequivalog
HMM Length314
AuthorHaft DH
Entry DateJul 14 2004 3:30PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model describes DMC1, a subfamily of a larger family of DNA repair and recombination proteins. It is eukaryotic only and most closely related to eukaryotic RAD51. It also resembles archaeal RadA (TIGR02236) and RadB (TIGR02237) and bacterial RecA (TIGR02012). It has been characterized for human as a recombinase active only in meiosis.
ReferencesRM 15164066 RT Human meiotic recombinase Dmc1 promotes ATP-dependent homologous DNA strand exchange. RA Sehorn MG, Sigurdsson S, Bussen W, Unger VM, Sung P. RL Nature. 2004 May 27;429(6990):433-7