HMM Summary Page: TIGR02235

Function1,4-dihydroxy-2-naphthoate phytyltransferase
Gene SymbolmenA
Trusted Cutoff225.00
Domain Trusted Cutoff225.00
Noise Cutoff155.10
Domain Noise Cutoff155.10
Isology Typeequivalog
EC Number2.5.1.-
HMM Length285
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryMenaquinone and ubiquinone
Gene Ontology TermGO:0004659: prenyltransferase activity molecular_function
GO:0042372: phylloquinone biosynthetic process biological_process
AuthorSelengut J
Entry DateJul 6 2004 4:21PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis family of phytyltransferases, found in plants and cyanobacteria, are involved in the biosythesis of phylloquinone (Vitamin K1). Phylloquinone is a critical component of photosystem I [1]. The closely related MenA enzyme from bacteria transfers a prenyl group (which only differs in the saturation of the isoprenyl groups) in the biosynthesis of menaquinone. Activity towards both substrates in certain organisms should be considered a possibility.
ReferencesRN [1] RM PMID: 3130097 RT Functional role of vitamin K in photosystem I of the cyanobacterium Synechocystis 6803. RA Biggins J, Mathis P. RL Biochemistry. 1988 Mar 8;27(5):1494-500.