HMM Summary Page: TIGR02224

Functiontyrosine recombinase XerC
Gene SymbolxerC
Trusted Cutoff335.15
Domain Trusted Cutoff335.15
Noise Cutoff316.75
Domain Noise Cutoff316.75
Isology Typeequivalog
HMM Length295
Mainrole CategoryDNA metabolism
Subrole CategoryDNA replication, recombination, and repair
Gene Ontology TermGO:0006310: DNA recombination biological_process
GO:0009009: site-specific recombinase activity molecular_function
AuthorHaft DH
Entry DateJun 16 2004 1:18PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe phage integrase family describes a number of recombinases with tyrosine active sites that transiently bind covalently to DNA. Many are associated with mobile DNA elements, including phage, transposons, and phase variation loci. This model represents XerC, one of two closely related chromosomal proteins along with XerD (TIGR02225). XerC and XerD are site-specific recombinases which help resolve chromosome dimers to monomers for cell division after DNA replication. In species with a large chromosome and homologs of XerC on other replicons, the chomosomal copy was preferred for building this model. This model does not detect all XerC, as some apparent XerC examples score in the gray zone between trusted (450) and noise (410) cutoffs, along with some XerD examples. XerC and XerD interact with cell division protein FtsK.
ReferencesDR PFAM; PF00589; Phage integrase family DR PFAM; PF02899; Phage integrase, N-terminal SAM-like domain RM 12823825 RT Species specificity in the activation of Xer recombination at dif by FtsK. RA Yates J, Aroyo M, Sherratt DJ, Barre FX. RL Mol Microbiol. 2003 Jul;49(1):241-9. DR HAMAP; MF_01808; 124 of 155