HMM Summary Page: TIGR02212

Functionlipoprotein releasing system, transmembrane protein, LolC/E family
Trusted Cutoff362.45
Domain Trusted Cutoff362.45
Noise Cutoff242.10
Domain Noise Cutoff242.10
Isology Typesubfamily
HMM Length411
Mainrole CategoryProtein fate
Subrole CategoryProtein and peptide secretion and trafficking
Gene Ontology TermGO:0005887: integral to plasma membrane cellular_component
GO:0042953: lipoprotein transport biological_process
GO:0042954: lipoprotein transporter activity molecular_function
AuthorHaft DH
Entry DateMay 26 2004 5:08PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM describes the LolC protein, and its paralog LolE found in some species. These proteins are homologous to permease proteins of ABC transporters. In some species, two paralogs occur, designated LolC and LolE. In others, a single form is found and tends to be designated LolC.
ReferencesDR PFAM; PF02687; FtsX RM 12823819 RT A mutation in the membrane subunit of an ABC transporter LolCDE complex causing outer membrane localization of lipoproteins against their inner membrane-specific signals. RA Narita S, Kanamaru K, Matsuyama S, Tokuda H. RL Mol Microbiol. 2003 Jul;49(1):167-77.
Genome PropertyGenProp0207: lipoprotein localization system lolABCDE (HMM)