HMM Summary Page: TIGR02211

Functionlipoprotein releasing system, ATP-binding protein
Gene SymbollolD
Trusted Cutoff307.75
Domain Trusted Cutoff307.75
Noise Cutoff284.45
Domain Noise Cutoff284.45
Isology Typeequivalog
EC Number3.6.3.-
HMM Length221
Mainrole CategoryProtein fate
Subrole CategoryProtein and peptide secretion and trafficking
Gene Ontology TermGO:0005524: ATP binding molecular_function
GO:0042953: lipoprotein transport biological_process
GO:0042954: lipoprotein transporter activity molecular_function
GO:0043190: ATP-binding cassette (ABC) transporter complex cellular_component
AuthorHaft DH
Entry DateMay 26 2004 4:06PM
Last ModifiedDec 21 2011 12:17PM
CommentThis model represents LolD, a member of the ABC transporter family (PF00005). LolD is involved in localization of lipoproteins in some bacteria. It works with a transmembrane protein LolC, which in some species is a paralogous pair LolC and LolE. Depending on whether the residue immediately following the new, modified N-terminal Cys residue, the nascent lipoprotein may be carried further by LolA and LolB to the outer membrane, or remain at the inner membrane. The top scoring proteins excluded by this model include homologs from the archaeal genus Methanosarcina.
ReferencesDR PF00005; ABC_tran RM 12823819 RT A mutation in the membrane subunit of an ABC transporter LolCDE complex causing outer membrane localization of lipoproteins against their inner membrane-specific signals. RA Narita S, Kanamaru K, Matsuyama S, Tokuda H. RL Mol Microbiol. 2003 Jul;49(1):167-77. DR HAMAP; MF_01708; 96 of 186
Genome PropertyGenProp0207: lipoprotein localization system lolABCDE (HMM)