HMM Summary Page: TIGR02207

Functionlipid A biosynthesis lauroyl (or palmitoleoyl) acyltransferase
Gene SymbollpxL
Trusted Cutoff297.80
Domain Trusted Cutoff297.80
Noise Cutoff248.25
Domain Noise Cutoff248.25
Isology Typesubfamily
EC Number2.3.1.-
HMM Length303
Mainrole CategoryCell envelope
Subrole CategoryBiosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Gene Ontology TermGO:0008415: acyltransferase activity molecular_function
GO:0009245: lipid A biosynthetic process biological_process
AuthorHaft DH
Entry DateMay 24 2004 3:54PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model represents a narrow clade of acyltransferases, nearly all of which transfer a lauroyl group to KDO2-lipid IV-A, a lipid A precursor; these proteins are termed lipid A biosynthesis lauroyl acyltransferase, HtrB. An exception is a closely related paralog of E. coli HtrB, LpxP, which acts in cold shock conditions by transferring a palmitoleoyl rather than lauroyl group to the lipid A precursor. Members of this family are homologous to the family of acyltransferases responsible for the next step in lipid A biosynthesis.
ReferencesRM 11830594 RT An Escherichia coli mutant lacking the cold shock-induced palmitoleoyltransferase of lipid A biosynthesis: absence of unsaturated acyl chains and antibiotic hypersensitivity at 12 degrees C. RA Vorachek-Warren MK, Carty SM, Lin S, Cotter RJ, Raetz CR. RL J Biol Chem. 2002 Apr 19;277(16):14186-93
Genome PropertyGenProp0204: KDO(2)-lipid A (Re LPS) biosynthesis and delivery (HMM)