HMM Summary Page: TIGR02203

Functionlipid A export permease/ATP-binding protein MsbA
Gene SymbolmsbA
Trusted Cutoff602.00
Domain Trusted Cutoff602.00
Noise Cutoff575.55
Domain Noise Cutoff575.55
Isology Typeequivalog
HMM Length572
Mainrole CategoryCell envelope
Subrole CategoryBiosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Gene Ontology TermGO:0005319: lipid transporter activity molecular_function
GO:0006869: lipid transport biological_process
AuthorHaft DH
Entry DateMay 20 2004 1:01PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis family consists of a single polypeptide chain transporter in the ATP-binding cassette (ABC) transporter family, MsbA, which exports lipid A. It may also act in multidrug resistance. Lipid A, a part of lipopolysaccharide, is found in the outer leaflet of the outer membrane of most Gram-negative bacteria. Members of this family are restricted to the Proteobacteria (although lipid A is more broadly distributed) and often are clustered with lipid A biosynthesis genes.
ReferencesDR PFAM; PF00664; ABC_membrane DR PFAMl PF00005; ABC_tran RM 12119303 RT ATPase activity of the MsbA lipid flippase of Escherichia coli. RA Doerrler WT, Raetz CR. RL J Biol Chem. 2002 Sep 27;277(39):36697-705. DR HAMAP; MF_01703; 106 of 106
Genome PropertyGenProp0204: KDO(2)-lipid A (Re LPS) biosynthesis and delivery (HMM)