| Accession | TIGR02203 |
| Name | MsbA_lipidA |
| Function | lipid A export permease/ATP-binding protein MsbA |
| Gene Symbol | msbA |
| Trusted Cutoff | 602.00 |
| Domain Trusted Cutoff | 602.00 |
| Noise Cutoff | 575.55 |
| Domain Noise Cutoff | 575.55 |
| Isology Type | equivalog |
| HMM Length | 572 |
| Mainrole Category | Cell envelope |
| Subrole Category | Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides |
| Gene Ontology Term | GO:0005319: lipid transporter activity molecular_function |
| | GO:0006869: lipid transport biological_process |
| Author | Haft DH |
| Entry Date | May 20 2004 1:01PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This family consists of a single polypeptide chain transporter in the ATP-binding cassette (ABC) transporter family, MsbA, which exports lipid A. It may also act in multidrug resistance. Lipid A, a part of lipopolysaccharide, is found in the outer leaflet of the outer membrane of most Gram-negative bacteria. Members of this family are restricted to the Proteobacteria (although lipid A is more broadly distributed) and often are clustered with lipid A biosynthesis genes. |
| References | DR PFAM; PF00664; ABC_membrane
DR PFAMl PF00005; ABC_tran
RM 12119303
RT ATPase activity of the MsbA lipid flippase of Escherichia coli.
RA Doerrler WT, Raetz CR.
RL J Biol Chem. 2002 Sep 27;277(39):36697-705.
DR HAMAP; MF_01703; 106 of 106 |
| Genome Property | GenProp0204: KDO(2)-lipid A (Re LPS) biosynthesis and delivery (HMM) |
