HMM Summary Page: TIGR02194

Functionglutaredoxin-like protein NrdH
Gene SymbolnrdH
Trusted Cutoff85.75
Domain Trusted Cutoff85.75
Noise Cutoff72.05
Domain Noise Cutoff72.05
Isology Typesubfamily
HMM Length72
AuthorSelengut J
Entry DateMay 17 2004 10:48AM
Last ModifiedMar 1 2011 11:50AM
CommentNrdH-redoxin is a representative of a class of small redox proteins that contain a conserved CXXC motif and are characterized by a glutaredoxin-like amino acid sequence and thioredoxin-like activity profile. Unlike other the glutaredoxins to which it is most closely related, NrdH aparrently does not interact with glutathione/glutathione reductase, but rather with thioredoxin reductase to catalyze the reduction of ribonucleotide reductase.
ReferencesRN [1] RM PMID: 11441020 RT Structural basis for the thioredoxin-like activity profile of the glutaredoxin-like NrdH-redoxin from Escherichia coli. RA Stehr M, Schneider G, Aslund F, Holmgren A, Lindqvist Y. RL J Biol Chem. 2001 Sep 21;276(38):35836-41. Epub 2001 Jul 05.
Genome PropertyGenProp0289: class I (aerobic) ribonucleotide reductase (HMM)