HMM Summary Page: TIGR02175

Function2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family
Trusted Cutoff81.10
Domain Trusted Cutoff81.10
Noise Cutoff72.40
Domain Noise Cutoff72.40
Isology Typesubfamily
HMM Length177
AuthorHaft DH
Entry DateMay 5 2004 3:48PM
Last ModifiedFeb 14 2011 3:27PM
CommentA number of anaerobic and microaerophilic species lack pyruvate dehydrogenase and have instead a four subunit, oxygen-sensitive pyruvate oxidoreductase, with either ferredoxins or flavodoxins (H. pylori) used as the acceptor. Several related four-subunit enzymes may exist in the same species. This model describes the gamma subunit. In Pyrococcus furious, enzymes active on pyruvate and 2-ketoisovalerate share a common gamma subunit.
ReferencesRM 8550425 RT Molecular and phylogenetic characterization of pyruvate and 2-ketoisovalerate ferredoxin oxidoreductases from Pyrococcus furiosus and pyruvate ferredoxin oxidoreductase from Thermotoga maritima. RA Kletzin A, Adams MW. RL J Bacteriol. 1996 Jan;178(1):248-57. DR PFAM; PF01558