HMM Summary Page: TIGR02170

Functionthymidylate synthase, flavin-dependent
Gene SymbolthyX
Trusted Cutoff87.90
Domain Trusted Cutoff87.90
Noise Cutoff67.10
Domain Noise Cutoff67.10
Isology Typeequivalog
EC Number2.1.1.148
HMM Length211
Mainrole CategoryPurines, pyrimidines, nucleosides, and nucleotides
Subrole Category2'-Deoxyribonucleotide metabolism
Gene Ontology TermGO:0009265: 2'-deoxyribonucleotide biosynthetic process biological_process
GO:0050797: thymidylate synthase (FAD) activity molecular_function
AuthorHaft DH
Entry DateApr 23 2004 2:52PM
Last ModifiedFeb 14 2011 3:27PM
CommentTwo forms of microbial thymidylate synthase are known: ThyA ( and ThyX ( This model describes ThyX, a homotetrameric flavoprotein. Both enzymes convert dUMP to dTMP. Under oxygen-limiting conditions, thyX can complement a thyA mutation.
ReferencesDR PFAM; PF02511; Thy1 RN [1] RM 15046578 RT Two distinct pathways for thymidylate (dTMP) synthesis in (hyper)thermophilic Bacteria and Archaea. RA Leduc D, Graziani S, Meslet-Cladiere L, Sodolescu A, Liebl U, Myllykallio H. RL Biochem Soc Trans. 2004 Apr;32(Pt 2):231-5. DR HAMAP; MF_01408; 48 of 48