Accession | TIGR02170 |
Name | thyX |
Function | thymidylate synthase, flavin-dependent |
Gene Symbol | thyX |
Trusted Cutoff | 87.90 |
Domain Trusted Cutoff | 87.90 |
Noise Cutoff | 67.10 |
Domain Noise Cutoff | 67.10 |
Isology Type | equivalog |
EC Number | 2.1.1.148 |
HMM Length | 211 |
Mainrole Category | Purines, pyrimidines, nucleosides, and nucleotides |
Subrole Category | 2'-Deoxyribonucleotide metabolism |
Gene Ontology Term | GO:0009265: 2'-deoxyribonucleotide biosynthetic process biological_process |
| GO:0050797: thymidylate synthase (FAD) activity molecular_function |
Author | Haft DH |
Entry Date | Apr 23 2004 2:52PM |
Last Modified | Feb 14 2011 3:27PM |
Comment | Two forms of microbial thymidylate synthase are known: ThyA (2.1.1.45) and ThyX (2.1.1.148). This model describes ThyX, a homotetrameric flavoprotein. Both enzymes convert dUMP to dTMP. Under oxygen-limiting conditions, thyX can complement a thyA mutation. |
References | DR PFAM; PF02511; Thy1
RN [1]
RM 15046578
RT Two distinct pathways for thymidylate (dTMP) synthesis in (hyper)thermophilic Bacteria and Archaea.
RA Leduc D, Graziani S, Meslet-Cladiere L, Sodolescu A, Liebl U, Myllykallio H.
RL Biochem Soc Trans. 2004 Apr;32(Pt 2):231-5.
DR HAMAP; MF_01408; 48 of 48 |