HMM Summary Page: TIGR02169

Functionchromosome segregation protein SMC
Gene Symbolsmc
Trusted Cutoff729.40
Domain Trusted Cutoff729.40
Noise Cutoff694.65
Domain Noise Cutoff694.65
Isology Typeequivalog
HMM Length1165
Mainrole CategoryCellular processes
Subrole CategoryCell division
Gene Ontology TermGO:0005524: ATP binding molecular_function
GO:0007059: chromosome segregation biological_process
GO:0030261: chromosome condensation biological_process
AuthorHaft DH
Entry DateApr 22 2004 10:42AM
Last ModifiedFeb 14 2011 3:27PM
CommentSMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent.
ReferencesRN [1] RM 14660695 RT The evolution of SMC proteins: phylogenetic analysis and structural implications. RA Cobbe N, Heck MM. RL Mol Biol Evol. 2004 Feb;21(2):332-47
Genome PropertyGenProp0201: SMC-ScpA-ScpB complex (HMM)